Research

Studies track how the immune system responds to tumors

Studies track how the immune system responds to tumors

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The University of Chicago and Johns Hopkins' Bloomberg~Kimmel Institute for Cancer Immunotherapy  have published a pair of studies looking at biomarkers involved in the immune system's response to tumors in the Nov. 7 issue of the Proceedings of the National Academy of Sciences. The University of Chicago studies are explained here. For the Johns Hopkins(...)

It seems that more young people in their 30s and 40s are being diagnosed. Are any studies looking at this and can they help younger patients?

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“I'm not aware of data to show that more young people are being diagnosed with lung cancer,”  says Russell K. Hales, M.D., a radiation oncologist, at the Johns Hopkins Kimmel Cancer Center on the Johns Hopkins Bayview campus. “But anecdotally, it is what I seem to be seeing as well.  What we tend to see(...)

What Makes Some Kidney Cancers Resistant to Immunotherapy?

What Makes Some Kidney Cancers Resistant to Immunotherapy?

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Suzanne Topalian, M.D., associate director of the Bloomberg~Kimmel Institute for Cancer Immunotherapy, is a pioneer in the search for biomarkers that predict responses to immunotherapy. In April at the American Association for Cancer Research meeting in New Orleans, Topalian and her colleagues presented data linking a virus-associated cancer, called Merkel cell carcinoma - to response(...)

Study: First Hints that Anti-PD-1 Therapy May Help Men with Advanced Prostate Cancer

Study: First Hints that Anti-PD-1 Therapy May Help Men with Advanced Prostate Cancer

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So-called anti-PD-1 drugs, which block the interaction between proteins on cancer and immune cells, are currently approved by the Food and Drug Administration for certain patients with melanoma and non-small cell lung, kidney and bladder cancers. Now, a new study led by scientists at Oregon Health & Science University's Knight Cancer Institute and partially funded(...)

Antibody May Provide a Strategy Against Metastatic Bone Cancer

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An antibody drug that targets part of the bone growth pathway can slow the growth of human osteosarcoma implanted in mice and prevent the tumor from spreading to other parts of the body, according to a study led by Johns Hopkins Kimmel Cancer Center scientists. Osteosarcoma is one of the most common bone tumors affecting children(...)

Two Studies Uncover Potential Treatments for Lethal Pediatric Brain Cancer DIPG

Two Studies Uncover Potential Treatments for Lethal Pediatric Brain Cancer DIPG

Posted by  | Childhood Cancer, Research

A rare cell line developed by Johns Hopkins researchers is giving scientists their first chance in decades to test new therapies for a lethal pediatric brain cancer that has few treatments. Kimmel Cancer Center scientist Eric H. Raabe, M.D., Ph.D., helped to develop the diffuse intrinsic pontine glioma (DIPG) cell line, grown from tumor tissue donated by(...)

Can biomarkers predict patients’ response to immunotherapy?

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Immunotherapy expert, Suzanne Topalian, M.D., delivered a presentation to a standing room only crowd at the 2016 American Society of Clinical Oncology (#ASCO16) regarding new directions in scientists’ search for biomarkers that identify patients and tumor types most likely to respond to immunotherapy drugs. Among the approaches is an immunohistochemistry test for the protein PD-L1,(...)

ASCO annual meeting features clinical trial results of immunotherapy for bladder and kidney cancer

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With recent FDA approvals of immunotherapy drugs for kidney and bladder cancer, patients now have more options to consider among their treatments. The 2016 ASCO annual meeting featured several new developments in these two cancers that seem to keep the momentum moving forward in this field. We asked Charles Drake, M.D., Ph.D., associate director of(...)