Immune Cells Hampered When Fighting Soft Tissue and Bone Sarcomas

Researchers at the Johns Hopkins Kimmel Cancer Center are studying the immune system to find what does and doesn't work to better fight soft tissue & bone cancer.

“The basis of successful immunotherapy lies in the ability of the immune system to recognize cancer as foreign and attack, and is dependent on genetics, host and environmental factors, and makeup of the tumor microenvironment,” says senior study author and pediatric hematologist-oncologist Nicolas Llosa, M.D., assistant professor of oncology at the Johns Hopkins University School of Medicine. “We need to understand the immune niche that sustains these tumors and how it supports tolerance, so we can determine what drug targets could be used to help mount a better response.”

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